Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IP6K1 | Q92551 | 3/20 | 0.35 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.32 |
| ▸ | PARP1 | P09874 | 3/20 | 0.31 |
| ▸ | PIM1 | P11309 | 2/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.30 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.30 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12623779 | 0.88 | ACVR1 (0.35) | CYP2C8ACVR1PARP1GRIN1GRIN2B | |
| SCHEMBL12623780 | 0.86 | ACVR1 (0.35) | ACVR1GRIN1GRIN2B | |
| SCHEMBL12624158 | 0.84 | CYP2C8 (0.35) | CYP2C8PIM1PIM2 | |
| SCHEMBL12623799 | 0.84 | GRIN1 (0.32) | CYP2C8PARP1PIM1PIM2GRIN1 | |
| SCHEMBL12388865 | 0.83 | IP6K1 (0.32) | IP6K1ACVR1 | |
| SCHEMBL12623647 | 0.83 | PDPK1 (0.35) | CYP2C8 | |
| SCHEMBL10257060 | 0.83 | PPARG (0.35) | GRIN1GRIN2B | |
| SCHEMBL12624639 | 0.83 | MAPT (0.40) | — | |
| SCHEMBL12623598 | 0.82 | PPARG (0.31) | CYP2C8GRIN1GRIN2B | |
| SCHEMBL12623895 | 0.82 | HTT (0.36) | GRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110104109-A1 | TETRACYCLIC INDOLE DERIVATIVES AND THEIR USE FOR TREATING OR PREVENTING VIRAL INFECTIONS | MERCK SHARP & DOHME CORP. | 2011-05-05 | — | — | US | disclosed |
| US-20110104109-A1 | TETRACYCLIC INDOLE DERIVATIVES AND THEIR USE FOR TREATING OR PREVENTING VIRAL INFECTIONS | MERCK SHARP & DOHME CORP. | 2011-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110104109-A1 | TETRACYCLIC INDOLE DERIVATIVES AND THEIR USE FOR TREATING OR PREVENTING VIRAL INFECTIONS | IDO1, IDO2, ZC3HAV1 | IP6K1 662/4885CYP2C8 1761/4885ACVR1 3281/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.