Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 14/20 | 0.63 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | GAK | O14976 | 1/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12629696 | 0.90 | TRPV1 (0.49) | TRPV1GAKRIPK2KDRMAPK14 | |
| SCHEMBL12629701 | 0.90 | TRPV1 (0.72) | TRPV1MAPK3 | |
| SCHEMBL12629831 | 0.88 | TRPV1 (0.48) | TRPV1GAKKDRDYRK3GSK3A | |
| SCHEMBL1859233 | 0.84 | TRPV1 (0.62) | TRPV1MAPK3MAPK10GAKDYRK3 | |
| SCHEMBL12629700 | 0.82 | TRPV1 (0.62) | TRPV1MAPK3 | |
| SCHEMBL1863016 | 0.81 | TRPV1 (0.65) | TRPV1MAPK3MAPK10GAKDYRK3 | |
| SCHEMBL5117433 | 0.80 | TRPV1 (0.66) | TRPV1MAPK3MAPK10GAKRIPK2 | |
| SCHEMBL5113971 | 0.79 | TRPV1 (0.65) | TRPV1MAPK3MAPK10GAKDYRK3 | |
| SCHEMBL12629704 | 0.79 | TRPV1 (0.57) | TRPV1MAPK3GAK | |
| SCHEMBL1860053 | 0.78 | TRPV1 (0.64) | TRPV1MAPK3MAPK10GAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7935702-B2 | Substituted biaryl quinolin-4-ylamine analogues | NEUROGEN CORPORATION (US) | 2011-05-03 | — | — | US | disclosed |