Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | REN | P00797 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | KDM5A | P29375 | 1/20 | 0.32 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.32 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13235909 | 0.79 | METAP1 (0.43) | HPGDCYP1A2 | |
| SCHEMBL1678163 | 0.78 | — | — | |
| SCHEMBL12153331 | 0.77 | CA1 (0.48) | CA1BLMCYP1A2 | |
| SCHEMBL11757116 | 0.76 | ACE2 (0.47) | MAPTTP53PKMKDM5AKDM7A | |
| SCHEMBL23971035 | 0.76 | MAPT (0.43) | MAPTTP53MEN1KMT2A | |
| SCHEMBL16882419 | 0.75 | CA1 (0.32) | CA1BLM | |
| SCHEMBL18050478 | 0.75 | CYP1A2 (0.45) | MAPTKDM5AKDM4CPHF8KDM2A | |
| SCHEMBL6156004 | 0.75 | CYP1A2 (0.45) | MAPTKDM5AKDM4CPHF8KDM2A | |
| SCHEMBL12153332 | 0.74 | CA1 (0.46) | CA1BLM | |
| SCHEMBL1678164 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011066241-A1 | FUSED TRICYCLIC COMPOUNDS AND DERIVATIVES THEREOF USEFUL FOR THE TREATMENT OF VIRAL DISEASES | SCHERING CORPORATION (US) | 2011-06-03 | — | — | WO | disclosed |