Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 9/20 | 0.63 |
| ▸ | DUSP22 | Q9NRW4 | 9/20 | 0.60 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12637121 | 0.87 | CFTR (0.62) | CFTRDUSP22NLRP3MEN1KMT2A | |
| SCHEMBL12637255 | 0.84 | DUSP22 (0.65) | CFTRDUSP22MEN1KMT2ADUSP3 | |
| SCHEMBL12637118 | 0.83 | CFTR (0.67) | CFTRDUSP22NLRP3MEN1KMT2A | |
| SCHEMBL12637159 | 0.83 | CFTR (0.84) | CFTRDUSP22NLRP3MEN1KMT2A | |
| SCHEMBL8004328 | 0.81 | CFTR (0.82) | CFTRDUSP22NLRP3MEN1KMT2A | |
| SCHEMBL12637254 | 0.79 | CFTR (0.73) | CFTRDUSP22NLRP3MEN1KMT2A | |
| SCHEMBL1888931 | 0.77 | CFTR (1.00) | CFTRDUSP22NLRP3MEN1KMT2A | |
| SCHEMBL1327129 | 0.77 | CFTR (1.00) | CFTRDUSP22NLRP3MEN1KMT2A | |
| SCHEMBL12637114 | 0.76 | CFTR (0.84) | CFTRDUSP22NLRP3MEN1KMT2A | |
| SCHEMBL12637158 | 0.76 | CFTR (0.84) | CFTRDUSP22NLRP3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110105565-A1 | WATER SOLUBLE SMALL MOLECULE INHIBITORS OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105565-A1 | WATER SOLUBLE SMALL MOLECULE INHIBITORS OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | CFTR, PKD1, PKD2 | CFTR 1/4885DUSP22 3990/4885NLRP3 852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.