Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 11/20 | 0.55 |
| ▸ | NTRK3 | Q16288 | 6/20 | 0.55 |
| ▸ | NTRK2 | Q16620 | 6/20 | 0.55 |
| ▸ | IGF1R | P08069 | 6/20 | 0.53 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.41 |
| ▸ | CDK2 | P24941 | 3/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
| ▸ | INSR | P06213 | 4/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12640221 | 0.92 | IGF1R (0.62) | NTRK1NTRK3NTRK2IGF1RCCNA2 | |
| SCHEMBL1374755 | 0.91 | NTRK1 (0.57) | NTRK1NTRK3NTRK2IGF1RCCNA2 | |
| SCHEMBL1373969 | 0.89 | NTRK1 (0.54) | NTRK1NTRK3NTRK2IGF1RINSR | |
| SCHEMBL4285299 | 0.89 | NTRK1 (0.55) | NTRK1NTRK3NTRK2IGF1RCCNA2 | |
| SCHEMBL12640064 | 0.89 | IGF1R (0.56) | NTRK1IGF1RCCNA2CDK2CCNA1 | |
| SCHEMBL4278038 | 0.88 | NTRK1 (0.56) | NTRK1NTRK3NTRK2IGF1RCCNA2 | |
| SCHEMBL4282616 | 0.88 | NTRK1 (0.55) | NTRK1NTRK3NTRK2IGF1RCCNA2 | |
| SCHEMBL1373571 | 0.88 | NTRK1 (0.53) | NTRK1NTRK3NTRK2IGF1RCCNA2 | |
| SCHEMBL4285425 | 0.88 | NTRK1 (0.54) | NTRK1NTRK3NTRK2IGF1RCCNA2 | |
| SCHEMBL4278208 | 0.87 | NTRK1 (0.70) | NTRK1NTRK3NTRK2IGF1RCCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7968583-B2 | Substituted pyrrolo-pyrazole derivatives active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-06-28 | — | — | US | disclosed |
| US-20090163503-A1 | SUBSTITUTED PYRROLO-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163503-A1 | SUBSTITUTED PYRROLO-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | MAP3K5, MAP3K19, MAP3K3 | NTRK1 1363/4885NTRK3 1220/4885NTRK2 2200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.