Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.59 |
| ▸ | BLM | P54132 | 2/20 | 0.59 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | DAO | P14920 | 2/20 | 0.43 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | EP300 | Q09472 | 1/20 | 0.41 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31160182 | 1.00 | PARP1 (0.59) | PARP1KDM4EALDH1A1LMNACYP1A2 | |
| SCHEMBL830808 | 0.74 | PARP1 (1.00) | PARP1KDM4EALDH1A1LMNACYP1A2 | |
| SCHEMBL2676355 | 0.74 | KDM4E (1.00) | PARP1KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL8173040 | 0.74 | PARP1 (0.51) | PARP1KDM4EALDH1A1LMNACYP1A2 | |
| SCHEMBL16139620 | 0.74 | KDM5C (0.47) | PARP1KDM4EALDH1A1LMNACYP1A2 | |
| SCHEMBL10028294 | 0.74 | DAO (0.50) | PARP1ALDH1A1DAOERCC1ERCC4 | |
| SCHEMBL14826545 | 0.74 | PARP1 (0.72) | PARP1KDM4ETNKS2ROCK2TNKS | |
| SCHEMBL8690342 | 0.73 | PARP1 (0.59) | PARP1KDM4EALDH1A1LMNACYP1A2 | |
| SCHEMBL151493 | 0.73 | PARP1 (0.59) | PARP1KDM4EALDH1A1LMNACYP1A2 | |
| SCHEMBL555325 | 0.73 | PARP1 (0.55) | PARP1KDM4EALDH1A1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-57212161-A | — | — | None | — | — | JP | disclosed |
| EP-3057586-A1 | BROMODOMAIN INHIBITORS | Celgene Quanticel Research, Inc. (US) | 2016-08-24 | — | — | EP | disclosed |
| WO-2015058160-A1 | BROMODOMAIN INHIBITORS | Quanticel Pharmaceuticals, Inc. (US) | 2015-04-23 | — | — | WO | disclosed |
| US-8877929-B2 | Process for synthesizing substituted isoquinolines | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-11-04 | — | — | US | disclosed |
| US-20130123503-A1 | Process for Synthesizing Substituted Isoquinolines | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-05-16 | — | — | US | disclosed |
| US-8357806-B2 | Process for synthesizing substituted isoquinolines | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-01-22 | — | — | US | disclosed |
| US-20120220774-A1 | Process for Synthesizing Substituted Isoquinolines | BRISTOL-MYERS SQUIBB COMPANY | 2012-08-30 | — | — | US | disclosed |
| US-8207341-B2 | Process or synthesizing substituted isoquinolines | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-06-26 | — | — | US | disclosed |
| US-7893071-B2 | Substituted phthalimide and isoquinoline derivatives; thalidomide analogs that lack the piperidine-2,6-dione moiety of thalidomide | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2011-02-22 | — | — | US | disclosed |
| US-7893071-B2 | Substituted phthalimide and isoquinoline derivatives; thalidomide analogs that lack the piperidine-2,6-dione moiety of thalidomide | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2011-02-22 | — | — | US | disclosed |
| EP-1389103-A4 | SYNTHESIS AND EVALUATION OF NOVEL PHTHALIMIDE MIMICS AS ANTI-ANGIOGENIC AGENTS | UNIV VIRGINIA (US) | 2005-09-14 | — | — | EP | disclosed |
| US-20040122030-A1 | Synthesis and evaluation of novel phthalimide mimics as anti-angiogenic | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2004-06-24 | — | — | US | disclosed |
| EP-1389103-A2 | SYNTHESIS AND EVALUATION OF NOVEL PHTHALIMIDE MIMICS AS ANTI-ANGIOGENIC AGENTS | THE UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2004-02-18 | — | — | EP | disclosed |
| WO-2002086078-A2 | SYNTHESIS AND EVALUATION OF NOVEL PHTHALIMIDE MIMICS AS ANTI-ANGIOGENIC AGENTS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2002-10-31 | — | — | WO | disclosed |
| EP-0165110-B1 | OPTICALLY ACTIVE ISOCARBOSTYRIL DERIVATIVES AND A METHOD OF PREPARING THE SAME | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1988-12-28 | — | — | EP | disclosed |
| US-4659833-A | FOUR OPTICAL ISOMERS OF 1-(2'-(O-METHOXYPHENYL)-1'-METHYLETHYLAMINO)-3-(4\"-ISOCARBOSTYRILOXY)-2 -PROPANOL ISOLATED BY LIQUID CHROMATOGRAPHY | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1987-04-21 | — | — | US | disclosed |
| EP-0165110-A1 | Optically active isocarbostyril derivatives and a method of preparing the same | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1985-12-18 | — | — | EP | disclosed |
| US-4517365-A | Isocarbostyril derivative | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1985-05-14 | — | — | US | disclosed |
| JP-S57212161-A | ISOCARBOSTYRIL DERIVATIVE | NISSHIN FLOUR MILLING CO LTD | 1982-12-27 | — | — | JP | disclosed |
| US-3974041-A | Image recording member with zeolitic water containing compounds | CANON KABUSHIKI KAISHA (JA) | 1976-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130123503-A1 | Process for Synthesizing Substituted Isoquinolines | POLQ, SFPQ, SYNCRIP | PARP1 295/4885KDM4E 1067/4885ALDH1A1 1643/4885 |
| US-20120220774-A1 | Process for Synthesizing Substituted Isoquinolines | POLQ, SFPQ, SYNCRIP | PARP1 295/4885KDM4E 1067/4885ALDH1A1 1643/4885 |
| US-20040122030-A1 | Synthesis and evaluation of novel phthalimide mimics as anti-angiogenic | KDR, FLT4, FLT1 | PARP1 2686/4885KDM4E 439/4885ALDH1A1 1161/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.