Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 16/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2037337 | 0.87 | CHEK1 (0.70) | CHEK1 | |
| SCHEMBL3310546 | 0.86 | CHEK1 (0.66) | CHEK1LMNAALDH1A1 | |
| SCHEMBL2035771 | 0.84 | CHEK1 (0.65) | CHEK1 | |
| SCHEMBL13415864 | 0.79 | CHEK1 (0.68) | CHEK1 | |
| SCHEMBL2033792 | 0.78 | CHEK1 (0.67) | CHEK1 | |
| SCHEMBL2036210 | 0.78 | CHEK1 (0.67) | CHEK1 | |
| SCHEMBL2031750 | 0.77 | CHEK1 (0.69) | CHEK1 | |
| SCHEMBL12184174 | 0.76 | CHEK1 (0.85) | CHEK1 | |
| SCHEMBL2036128 | 0.76 | CHEK1 (0.73) | CHEK1 | |
| SCHEMBL3320551 | 0.75 | CHEK1 (0.67) | CHEK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379510-B1 | ARYL AND HETEROARYL UREA CHK1 INHIBITORS FOR USE AS RADIOSENSITIZERS AND CHEMOSENSITIZERS | ICOS CORP (US) | 2011-06-01 | — | — | EP | disclosed |