Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPID | Q08752 | 6/20 | 0.68 |
| ▸ | PPIB | P23284 | 3/20 | 0.51 |
| ▸ | PPIG | Q13427 | 2/20 | 0.51 |
| ▸ | PPIA | P62937 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | ANPEP | P15144 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGAV | P06756 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12643966 | 1.00 | PPID (0.68) | PPIDPPIBPPIGPPIAHTT | |
| SCHEMBL16270312 | 0.97 | PPID (0.69) | PPIDPPIBPPIGPPIAHTT | |
| SCHEMBL12643652 | 0.97 | PPID (0.69) | PPIDPPIBPPIGPPIAHTT | |
| SCHEMBL19882161 | 0.88 | PPID (0.53) | PPIDHTTCASP1CA1CA2 | |
| SCHEMBL12643638 | 0.87 | PPID (0.57) | PPIDPPIBPPIGPPIAHTT | |
| SCHEMBL2039557 | 0.86 | FOLH1 (0.56) | PPIDFOLH1ITGB3ITGAV | |
| SCHEMBL2034565 | 0.83 | FOLH1 (0.51) | PPIDFOLH1ITGB3ITGAV | |
| SCHEMBL2039871 | 0.81 | PPID (1.00) | PPIDPPIBPPIGPPIAHTT | |
| SCHEMBL2040765 | 0.79 | PPID (1.00) | PPIDPPIBPPIGPPIAATM | |
| SCHEMBL12643650 | 0.79 | MAPT (0.48) | PPIDCA1CA2L3MBTL1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8901295-B2 | Inhibitors of cyclophilins and uses thereof | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2014-12-02 | — | — | US | disclosed |
| WO-2011076784-A2 | NEW INHIBITORS OF CYCLOPHILINS AND USES THEREOF | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2011-06-30 | — | — | WO | disclosed |