Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Betamethasone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 8/20 | 0.92 |
| ▸ | HIF1A | Q16665 | 8/20 | 0.92 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.92 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.92 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.92 |
| ▸ | PGR | P06401 | 3/20 | 0.92 |
| ▸ | TSHR | P16473 | 2/20 | 0.92 |
| ▸ | AR | P10275 | 2/20 | 0.92 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.92 |
| ▸ | MEN1 | O00255 | 1/20 | 0.92 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.92 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.92 |
| ▸ | APEX1 | P27695 | 1/20 | 0.92 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.92 |
| ▸ | IKBKB | O14920 | 1/20 | 0.92 |
| ▸ | CHUK | O15111 | 1/20 | 0.92 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.92 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.92 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.92 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.92 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dexamethasone SCHEMBL27725250 | 1.00 | HIF1A (0.92) | HIF1ANR3C1CYP3A4HSD17B10NFKB1 | |
| Betamethasone SCHEMBL29053197 | 1.00 | HIF1A (0.92) | HIF1ANR3C1CYP3A4HSD17B10NFKB1 | |
| Betamethasone SCHEMBL3456100 | 0.97 | HIF1A (0.86) | HIF1ANR3C1CYP3A4HSD17B10NFKB1 | |
| Betamethasone SCHEMBL9112497 | 0.97 | HIF1A (0.86) | HIF1ANR3C1CYP3A4HSD17B10NFKB1 | |
| Dexamethasone SCHEMBL8506918 | 0.97 | HIF1A (0.98) | HIF1ANR3C1CYP3A4HSD17B10NFKB1 | |
| Dexamethasone SCHEMBL8159683 | 0.96 | HIF1A (0.96) | HIF1ANR3C1CYP3A4HSD17B10NFKB1 | |
| Dexamethasone SCHEMBL9117488 | 0.96 | HIF1A (0.96) | HIF1ANR3C1CYP3A4HSD17B10NFKB1 | |
| Betamethasone SCHEMBL9117494 | 0.96 | HIF1A (0.96) | HIF1ANR3C1CYP3A4HSD17B10NFKB1 | |
| Betamethasone SCHEMBL23022353 | 0.96 | HIF1A (1.00) | HIF1ANR3C1CYP3A4HSD17B10NFKB1 | |
| Betamethasone SCHEMBL21790369 | 0.96 | HIF1A (1.00) | HIF1ANR3C1CYP3A4HSD17B10NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 82 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7187980-B2 | Cardiac lead with steroid eluting ring | OSCOR INC. (US) | 2007-03-06 | — | — | US | claimed |
| US-20070020325-A1 | Hydrogel composition | HISAMITSU PHARMACEUTICAL CO., INC. (JP) | 2007-01-25 | — | — | US | claimed |
| US-20050271725-A1 | Adhesive gel composition for iontophoresis preparation and process for producing the same | HISAMITSU PHARMACEUTICAL CO., INC. (JP) | 2005-12-08 | — | — | US | claimed |
| EP-1547579-A1 | ADHESIVE GEL COMPOSITION FOR IONTOPHORESIS PREPARATION AND PROCESS FOR PRODUCING THE SAME | HISAMITSU PHARMACEUTICAL CO., INC. (JP) | 2005-06-29 | — | — | EP | claimed |
| EP-1441806-A2 | CARDIAC LEAD WITH STEROID ELUTING RING | Oscor Inc. (US) | 2004-08-04 | — | — | EP | claimed |
| WO-2003041793-A2 | CARDIAC LEAD WITH STEROID ELUTING RING | OSCOR INC. (US) | 2003-05-22 | — | — | WO | claimed |
| US-20030093136-A1 | Cardiac lead with steroid eluting ring | WELLS FARGO BANK, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT | 2003-05-15 | — | — | US | claimed |
| US-20230285293-A1 | PHARMACEUTICAL COMPOSITION OF INTRA-ARTICULAR CORTICOSTEROID FOR PAIN CONTROL | TLC BIOPHARMACEUTICALS, INC. | 2023-09-14 | — | — | US | disclosed |
| US-20230285565-A1 | POLYTETRAFLUOROETHYLENE CO-POLYMER EMULSIONS | W. L. GORE & ASSOCIATES, INC. | 2023-09-14 | — | — | US | disclosed |
| CN-116348093-A | Pharmaceutical composition of intra-articular corticosteroid for pain control | TLC生物医药公司 | 2023-06-27 | — | — | CN | disclosed |
| EP-4192426-A1 | PHARMACEUTICAL COMPOSITION OF INTRA-ARTICULAR CORTICOSTEROID FOR PAIN CONTROL | TLC Biopharmaceuticals, Inc. (US) | 2023-06-14 | — | — | EP | disclosed |
| US-11642412-B2 | Polytetrafluoroethylene co-polymer emulsions | W. L. GORE & ASSOCIATES, INC. (US) | 2023-05-09 | — | — | US | disclosed |
| US-20220401626-A1 | LIQUID COMPOSITION AND POROUS HARDENED MATERIAL COMPRISING TETRAFLUOROETHYLENE AND VINYL MOIETY CO-POLYMERS | W. L. GORE & ASSOCIATES, INC. | 2022-12-22 | — | — | US | disclosed |
| US-20040054389-A1 | Implantable cardiac lead having removable fluid delivery port | WELLS FARGO BANK, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT | 2004-03-18 | — | — | US | disclosed |
| WO-2004011081-A1 | EPICARDIAL SCREW-IN LEAD | OSCOR INC. (US) | 2004-02-05 | — | — | WO | disclosed |
| US-6671562-B2 | High impedance drug eluting cardiac lead | OSCOR INC. | 2003-12-30 | — | — | US | disclosed |
| WO-2003041792-A2 | HIGH IMPEDANCE DRUG ELUTING CARDIAC LEAD | OSCOR INC. (US) | 2003-05-22 | — | — | WO | disclosed |
| WO-2003041793-A2 | CARDIAC LEAD WITH STEROID ELUTING RING | OSCOR INC. (US) | 2003-05-22 | — | — | WO | disclosed |
| US-20030093136-A1 | Cardiac lead with steroid eluting ring | WELLS FARGO BANK, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT | 2003-05-15 | — | — | US | disclosed |
| US-20030093138-A1 | High impedance drug eluting cardiac lead | WELLS FARGO BANK, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT | 2003-05-15 | — | — | US | disclosed |