Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LATS1 | O95835 | 19/20 | 0.51 |
| ▸ | LATS2 | Q9NRM7 | 13/20 | 0.47 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12657460 | 0.75 | LATS1 (0.49) | LATS1LATS2PDE5A | |
| SCHEMBL14344353 | 0.71 | LATS1 (0.89) | LATS1LATS2PDE5A | |
| SCHEMBL16963713 | 0.69 | LATS1 (1.00) | LATS1LATS2PDE5A | |
| SCHEMBL786548 | 0.68 | LATS1 (0.58) | LATS1LATS2PDE5A | |
| SCHEMBL801605 | 0.68 | AURKA (0.79) | LATS1 | |
| SCHEMBL26177128 | 0.67 | LATS1 (1.00) | LATS1LATS2 | |
| SCHEMBL31375190 | 0.67 | LATS1 (1.00) | LATS1LATS2 | |
| SCHEMBL20548215 | 0.65 | LATS1 (1.00) | LATS1LATS2 | |
| SCHEMBL14529244 | 0.65 | MAPT (0.36) | PDE5A | |
| SCHEMBL786649 | 0.65 | LATS1 (0.54) | LATS1LATS2PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317448-B2 | PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMA (US) | 2011-05-04 | — | — | EP | disclosed |