Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 1/20 | 0.48 |
| ▸ | CSNK1D | P48730 | 11/20 | 0.47 |
| ▸ | CSNK1E | P49674 | 10/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | PRKACA | P17612 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12664250 | 0.92 | AURKA (0.55) | PIK3CGCSNK1DCSNK1ERIPK1PIK3CA | |
| SCHEMBL12664154 | 0.91 | PIK3CG (0.47) | PIK3CGCSNK1DCSNK1ERIPK1PIK3CA | |
| SCHEMBL12664179 | 0.90 | PIK3CA (0.48) | PIK3CGCSNK1DCSNK1ERIPK1PIK3CA | |
| SCHEMBL12664478 | 0.90 | CSNK1D (0.48) | PIK3CGCSNK1DCSNK1ERIPK1PIK3CA | |
| SCHEMBL12664315 | 0.89 | FYN (0.48) | PIK3CGCSNK1DCSNK1ERIPK1PIK3CA | |
| SCHEMBL12664279 | 0.89 | KDR (0.46) | PIK3CGCSNK1DCSNK1ERIPK1PIK3CA | |
| SCHEMBL12664471 | 0.89 | PIK3CA (0.45) | PIK3CGCSNK1DCSNK1ERIPK1PIK3CA | |
| SCHEMBL12664053 | 0.88 | CSNK1D (0.52) | PIK3CGCSNK1DCSNK1ERIPK1PIK3CA | |
| SCHEMBL12664405 | 0.88 | CSNK1D (0.53) | PIK3CGCSNK1DCSNK1ERIPK1PIK3CA | |
| SCHEMBL12664254 | 0.88 | PIK3CA (0.49) | PIK3CGCSNK1DCSNK1ERIPK1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110105457-A1 | HETEROCYCLIC COMPOUND HAVING INHIBITORY ACTIVITY ON PI3K | SHIONOGI & CO., LTD. | 2011-05-05 | — | — | US | disclosed |
| US-20110105457-A1 | HETEROCYCLIC COMPOUND HAVING INHIBITORY ACTIVITY ON PI3K | SHIONOGI & CO., LTD. | 2011-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105457-A1 | HETEROCYCLIC COMPOUND HAVING INHIBITORY ACTIVITY ON PI3K | MTOR, STAT3, PIK3CD | PIK3CG 11/4885CSNK1D 1952/4885CSNK1E 1619/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.