Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.53 |
| ▸ | RIPK1 | Q13546 | 12/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12664646 | 0.90 | PIK3CA (0.57) | PIK3CAPIK3CGPIK3CDRIPK1 | |
| SCHEMBL12664371 | 0.89 | PIK3CA (0.50) | PIK3CAPIK3CGPIK3CDRIPK1 | |
| SCHEMBL12664447 | 0.84 | PIK3CG (0.55) | PIK3CAPIK3CGPIK3CDRIPK1CYP3A4 | |
| SCHEMBL799204 | 0.81 | PIK3CG (0.53) | PIK3CAPIK3CGPIK3CDRIPK1 | |
| SCHEMBL12664707 | 0.80 | PIK3CA (0.53) | PIK3CAPIK3CGPIK3CDRIPK1 | |
| SCHEMBL12664704 | 0.79 | PIK3CA (0.51) | PIK3CAPIK3CGPIK3CDRIPK1 | |
| SCHEMBL13188740 | 0.78 | PIK3CA (0.51) | PIK3CAPIK3CGPIK3CDRIPK1 | |
| SCHEMBL12664398 | 0.78 | PIK3CA (0.53) | PIK3CAPIK3CGPIK3CDRIPK1ADORA2A | |
| SCHEMBL12664684 | 0.78 | PIK3CG (0.50) | PIK3CAPIK3CGPIK3CDRIPK1 | |
| SCHEMBL13188162 | 0.77 | PIK3CA (0.50) | PIK3CAPIK3CGPIK3CDRIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110105457-A1 | HETEROCYCLIC COMPOUND HAVING INHIBITORY ACTIVITY ON PI3K | SHIONOGI & CO., LTD. | 2011-05-05 | — | — | US | disclosed |
| US-20110105457-A1 | HETEROCYCLIC COMPOUND HAVING INHIBITORY ACTIVITY ON PI3K | SHIONOGI & CO., LTD. | 2011-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105457-A1 | HETEROCYCLIC COMPOUND HAVING INHIBITORY ACTIVITY ON PI3K | MTOR, STAT3, PIK3CD | PIK3CA 8/4885PIK3CG 11/4885PIK3CD 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.