Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.55 |
| ▸ | MET | P08581 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.55 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.55 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | SPR | P35270 | 1/20 | 0.36 |
| ▸ | NGFR | P08138 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12668951 | 0.91 | CHEK1 (0.51) | CHEK1METGSK3BLIMK1DYRK1A | |
| SCHEMBL12668956 | 0.85 | GSK3B (0.48) | CHEK1METGSK3BLIMK1DYRK1A | |
| SCHEMBL12668282 | 0.84 | KDM4E (0.36) | CHEK1METGSK3BLIMK1DYRK1A | |
| SCHEMBL12667317 | 0.83 | GSK3B (0.46) | CHEK1METGSK3BLIMK1DYRK1A | |
| SCHEMBL21813713 | 0.83 | CHEK1 (0.57) | CHEK1METGSK3BLIMK1DYRK1A | |
| SCHEMBL12668261 | 0.81 | CHEK1 (0.44) | CHEK1METGSK3BLIMK1DYRK1A | |
| SCHEMBL12668046 | 0.79 | CHEK1 (0.45) | CHEK1METGSK3BLIMK1DYRK1A | |
| SCHEMBL21813347 | 0.78 | CHEK1 (0.52) | CHEK1METGSK3BLIMK1DYRK1A | |
| SCHEMBL21813486 | 0.77 | CHEK1 (0.51) | CHEK1METGSK3BLIMK1DYRK1A | |
| SCHEMBL12667345 | 0.76 | CHEK1 (0.42) | CHEK1METGSK3BLIMK1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011060036-A1 | BICYCLIC COMPOUNDS AND METHODS OF USE THEREOF | SCHERING CORPORATION (US) | 2011-05-19 | — | — | WO | disclosed |