Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 18/20 | 0.72 |
| ▸ | VEGFA | P15692 | 10/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL272670 | 0.87 | EGLN1 (0.88) | EGLN1VEGFAKDM4ETP53CYP2D6 | |
| SCHEMBL272502 | 0.84 | EGLN1 (0.71) | EGLN1VEGFAKDM4ETP53CYP2D6 | |
| SCHEMBL273704 | 0.84 | EGLN1 (1.00) | EGLN1VEGFAKDM4ETP53CYP2D6 | |
| SCHEMBL271709 | 0.81 | EGLN1 (0.64) | EGLN1VEGFAKDM4ETP53CYP2D6 | |
| SCHEMBL1774277 | 0.81 | EGLN1 (1.00) | EGLN1VEGFAKDM4EHTT | |
| SCHEMBL271531 | 0.80 | EGLN1 (0.63) | EGLN1VEGFA | |
| SCHEMBL12649393 | 0.80 | EGLN1 (0.88) | EGLN1VEGFACYP2D6SMN1; SMN2 | |
| SCHEMBL12599456 | 0.80 | EGLN1 (0.80) | EGLN1VEGFAKDM4ETP53CYP2D6 | |
| SCHEMBL272385 | 0.80 | EGLN1 (0.76) | EGLN1VEGFAKDM4EHTTSMN1; SMN2 | |
| SCHEMBL24512412 | 0.79 | EGLN1 (0.78) | EGLN1VEGFAKDM4ETP53CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011057115-A1 | PROLYL HYDROXYLASE INHIBITORS | AKEBIA THERAPEUTICS INC. (US) | 2011-05-12 | — | — | WO | disclosed |