Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 6/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12669808 | 0.93 | BRAF (0.51) | EGFRKCNH2BRAFNR1I2 | |
| SCHEMBL1881629 | 0.92 | BRAF (0.53) | EGFRKCNH2BRAFNR1I2 | |
| SCHEMBL1872245 | 0.91 | KCNH2 (0.44) | EGFRKCNH2BRAFNR1I2 | |
| SCHEMBL1890075 | 0.90 | BRAF (0.46) | KCNH2BRAFNR1I2 | |
| SCHEMBL1870084 | 0.90 | BRAF (0.44) | EGFRBRAFNR1I2 | |
| SCHEMBL1866857 | 0.87 | BRAF (0.44) | BRAFNR1I2 | |
| SCHEMBL12669624 | 0.86 | BRAF (0.40) | EGFRBRAF | |
| SCHEMBL9987017 | 0.86 | BRAF (0.48) | BRAFNR1I2 | |
| SCHEMBL14865885 | 0.86 | BRAF (0.54) | BRAFNR1I2 | |
| SCHEMBL1866858 | 0.86 | BRAF (0.46) | EGFRBRAFNR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011059610-A1 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-05-19 | — | — | WO | disclosed |