Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 14/20 | 0.43 |
| ▸ | CTSC | P53634 | 1/20 | 0.32 |
| ▸ | FASN | P49327 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1867296 | 0.79 | CSF1R (0.53) | CSF1RNTRK1KITAXLFLT3 | |
| SCHEMBL1861097 | 0.79 | CSF1R (0.59) | CSF1R | |
| SCHEMBL12670009 | 0.78 | CSF1R (0.50) | CSF1RNTRK1KITAXLFLT3 | |
| SCHEMBL12422511 | 0.78 | CSF1R (0.50) | CSF1RNTRK1KITAXLFLT3 | |
| SCHEMBL12669936 | 0.77 | CSF1R (0.64) | CSF1RNTRK1KITAXLFLT3 | |
| SCHEMBL5012417 | 0.73 | GAA (0.38) | CSF1RKMT2A | |
| SCHEMBL12408180 | 0.72 | CSF1R (0.39) | CSF1RNTRK1KITAXLFLT3 | |
| SCHEMBL12381938 | 0.71 | CSF1R (0.42) | CSF1R | |
| SCHEMBL5012415 | 0.71 | CDC7 (0.36) | CSF1RKMT2A | |
| SCHEMBL1860806 | 0.70 | CSF1R (0.47) | CSF1RNTRK1KITAXLFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2021335-B1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2011-05-25 | — | — | EP | disclosed |