Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 15/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12669225 | 0.93 | BRAF (0.41) | BRAFNR1I2EGFRKCNH2 | |
| SCHEMBL1868475 | 0.92 | BRAF (0.51) | BRAFNR1I2EGFR | |
| SCHEMBL1872453 | 0.89 | BRAF (0.54) | BRAFKCNH2 | |
| SCHEMBL12669105 | 0.89 | BRAF (0.54) | BRAFKCNH2 | |
| SCHEMBL1876653 | 0.89 | BRAF (0.54) | BRAFEGFR | |
| SCHEMBL1870084 | 0.88 | BRAF (0.44) | BRAFNR1I2EGFR | |
| SCHEMBL12669242 | 0.88 | BRAF (0.47) | BRAFNR1I2EGFR | |
| SCHEMBL12670282 | 0.86 | BRAF (0.49) | BRAFNR1I2 | |
| SCHEMBL1873864 | 0.83 | NR1I2 (0.39) | BRAFNR1I2EGFRKCNH2 | |
| SCHEMBL12670302 | 0.83 | NR1I2 (0.53) | BRAFNR1I2EGFRKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011059610-A1 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-05-19 | — | — | WO | disclosed |