Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CDK7 | P50613 | 1/20 | 0.42 |
| ▸ | CCNH | P51946 | 1/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.42 |
| ▸ | IDH1 | O75874 | 6/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2742720 | 0.93 | MAPT (0.51) | MAPTGAAPOLBTP53LMNA | |
| SCHEMBL2030411 | 0.91 | MAPT (0.51) | MAPTGAAPOLBTP53LMNA | |
| SCHEMBL2036273 | 0.88 | MAPT (0.47) | MAPTGAAPOLBTP53LMNA | |
| SCHEMBL2034633 | 0.85 | MAPT (0.47) | MAPTGAAPOLBTP53LMNA | |
| SCHEMBL12670163 | 0.83 | GAA (0.56) | MAPTGAAPOLBTP53LMNA | |
| SCHEMBL12670833 | 0.83 | MEN1 (0.49) | MAPTGAAPOLBTP53LMNA | |
| SCHEMBL12670142 | 0.82 | MCL1 (0.51) | MAPTGAAPOLBTP53LMNA | |
| SCHEMBL2031022 | 0.82 | MAPT (0.42) | MAPTGAAPOLBTP53LMNA | |
| SCHEMBL2033632 | 0.80 | PPARG (0.45) | MAPTGAAPOLBLMNAMEN1 | |
| SCHEMBL2029584 | 0.79 | SGK1 (0.43) | MAPTGAAPOLBTP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7939551-B2 | for diabetes mellitus and other metabolic disorders; compounds of given formula such as sulfonamides and an antidiabetic agent such as sulfonylureas, biguanides, glitazones, alpha-glucosidase inhibitors, glucagon antagonists | AMGEN INC. (US) | 2011-05-10 | — | — | US | disclosed |