Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1857184 | 0.90 | KCNH2 (0.62) | KCNH2GCK | |
| SCHEMBL1857187 | 0.90 | KCNH2 (0.62) | KCNH2GCK | |
| SCHEMBL1857543 | 0.89 | GCK (0.56) | KCNH2GCK | |
| SCHEMBL1857545 | 0.89 | GCK (0.56) | KCNH2GCK | |
| SCHEMBL1857668 | 0.88 | KCNH2 (0.53) | KCNH2GCK | |
| SCHEMBL1863545 | 0.87 | KCNH2 (0.55) | KCNH2GCK | |
| SCHEMBL1864748 | 0.87 | KCNH2 (0.55) | KCNH2GCK | |
| SCHEMBL1855856 | 0.86 | KCNH2 (0.48) | KCNH2GCK | |
| SCHEMBL1856508 | 0.85 | KCNH2 (0.49) | KCNH2GCK | |
| SCHEMBL1856507 | 0.85 | KCNH2 (0.49) | KCNH2GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7935699-B2 | Pyrazole glucokinase activators | HOFFMANN-LA ROCHE INC. (US) | 2011-05-03 | — | — | US | disclosed |
| US-20080021032-A1 | Pyrazole glucokinase activators | BERTHEL STEVEN JOSEPH | 2008-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080021032-A1 | Pyrazole glucokinase activators | GCKR, GCK, GALK1 | KCNH2 2241/4885GCK 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.