Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 9/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 6/20 | 0.34 |
| ▸ | LCK | P06239 | 3/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14235797 | 0.88 | TNK2 (0.38) | TNK2CHEK1OPRM1OPRL1LCK | |
| SCHEMBL12095402 | 0.87 | AKT1 (0.41) | TNK2CHEK1 | |
| Hydrochloric Acid SCHEMBL1900324 | 0.87 | AKT1 (0.40) | TNK2CHEK1 | |
| SCHEMBL1903880 | 0.86 | TNK2 (0.37) | TNK2CHEK1OPRM1OPRL1LCK | |
| SCHEMBL14119016 | 0.82 | AKT1 (0.40) | TNK2CHEK1LCKAURKA | |
| SCHEMBL1906685 | 0.79 | AKT1 (0.39) | CHEK1 | |
| SCHEMBL1904617 | 0.77 | CHEK1 (0.36) | TNK2CHEK1OPRM1LCKAURKA | |
| SCHEMBL1904185 | 0.76 | AURKA (0.37) | TNK2CHEK1LCKAURKA | |
| SCHEMBL1904665 | 0.75 | AKT1 (0.40) | — | |
| SCHEMBL1901112 | 0.75 | CHEK1 (0.43) | CHEK1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011055115-A1 | AKT / PKB INHIBITORS | ALMAC DISCOVERY LIMITED (GB) | 2011-05-12 | — | — | WO | disclosed |