Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VEGFA | P15692 | 7/20 | 0.57 |
| ▸ | EGLN1 | Q9GZT9 | 7/20 | 0.57 |
| ▸ | ATM | Q13315 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CCR3 | P51677 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL278211 | 0.87 | VEGFA (0.75) | VEGFAEGLN1ATMALDH1A1CCR3 | |
| SCHEMBL12598834 | 0.87 | VEGFA (0.69) | VEGFAEGLN1ATMALDH1A1CCR3 | |
| SCHEMBL12649390 | 0.83 | MEN1 (0.58) | VEGFAEGLN1CCR3MEN1KMT2A | |
| SCHEMBL12649394 | 0.76 | VEGFA (0.70) | VEGFAEGLN1 | |
| SCHEMBL278202 | 0.74 | VEGFA (1.00) | VEGFAEGLN1ALDH1A1KMT2AKDM4E | |
| SCHEMBL20763920 | 0.74 | VEGFA (0.57) | VEGFAEGLN1ATMALDH1A1CCR3 | |
| SCHEMBL12598832 | 0.73 | VEGFA (0.73) | VEGFAEGLN1ALDH1A1KDM4E | |
| SCHEMBL273037 | 0.73 | EGLN1 (0.87) | VEGFAEGLN1ALDH1A1MEN1KMT2A | |
| SCHEMBL277668 | 0.72 | EGLN1 (0.85) | VEGFAEGLN1KDM4ESMN1; SMN2 | |
| SCHEMBL273696 | 0.72 | EGLN1 (0.85) | VEGFAEGLN1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2496236-B1 | PROLYL HYDROXYLASE INHIBITORS | AERPIO THERAPEUTICS INC (US) | 2013-05-01 | — | — | EP | disclosed |
| WO-2011057121-A1 | COMPOSITIONS AND METHODS FOR TREATING COLITIS | AKEBIA THERAPEUTICS INC. (US) | 2011-05-12 | — | — | WO | disclosed |