Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.72 |
| ▸ | ROS1 | P08922 | 8/20 | 0.66 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.40 |
| ▸ | ACVR2A | P27037 | 4/20 | 0.38 |
| ▸ | TGFBR2 | P37173 | 4/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.35 |
| ▸ | CLK3 | P49761 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL988741 | 0.90 | FLT3 (0.69) | FLT3ROS1DYRK1AACVR2ATGFBR2 | |
| SCHEMBL12678142 | 0.87 | FLT3 (0.80) | FLT3ROS1DYRK1AACVR2ATGFBR2 | |
| SCHEMBL988748 | 0.85 | FLT3 (0.80) | FLT3ROS1DYRK1AACVR2ATGFBR2 | |
| SCHEMBL987949 | 0.85 | FLT3 (0.73) | FLT3ROS1ALK | |
| SCHEMBL988400 | 0.84 | FLT3 (1.00) | FLT3ROS1DYRK1AACVR2ATGFBR2 | |
| SCHEMBL990161 | 0.83 | FLT3 (0.77) | FLT3ROS1DYRK1AMAOAALK | |
| SCHEMBL989322 | 0.82 | ROS1 (0.80) | FLT3ROS1ALKTGFBR1 | |
| SCHEMBL12678148 | 0.82 | FLT3 (0.62) | FLT3ROS1DYRK1AMAOAALK | |
| SCHEMBL12948955 | 0.82 | FLT3 (0.62) | FLT3ROS1DYRK1AMAOAALK | |
| SCHEMBL988180 | 0.82 | ROS1 (0.74) | FLT3ROS1ALKTGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8273880-B2 | Pyrazole compounds with inhibitory activity against ROS kinase | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2012-09-25 | — | — | US | disclosed |
| US-20110015395-A1 | PYRAZOLE COMPOUNDS WITH INHIBITORY ACTIVITY AGAINST ROS KINASE | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2011-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110015395-A1 | PYRAZOLE COMPOUNDS WITH INHIBITORY ACTIVITY AGAINST ROS KINASE | ROS1, PDPK1, MAP3K19 | FLT3 206/4885ROS1 1/4885DYRK1A 536/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.