SCHEMBL12680478

SCHEMBL12680478

CCN(Cc1ccc(C)cc1)Cc1ccc(-c2ccc(CN(CC)Cc3ccc(C)cc3)cc2)cc1

nearest known ligand 0.75

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ HRH3 Q9Y5N1 5/20 0.75
▸ CYP19A1 P11511 1/20 0.44
▸ TAAR1 Q96RJ0 1/20 0.42
▸ PYCR1 P32322 2/20 0.42
▸ HDAC8 Q9BY41 1/20 0.42
▸ HDAC6 Q9UBN7 1/20 0.42
▸ KDM4E B2RXH2 1/20 0.42
▸ CNR2 P34972 2/20 0.41
▸ KCNH2 Q12809 1/20 0.41
▸ TSHR P16473 1/20 0.41
▸ MAPK1 P28482 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12763728 0.93 HRH3 (0.62) HRH3PYCR1HDAC8HDAC6KDM4E
SCHEMBL12679030 0.92 HRH3 (0.64) HRH3CYP19A1TAAR1PYCR1HDAC8
SCHEMBL5925786 0.89 HRH3 (0.70) HRH3PYCR1HDAC8HDAC6CNR2
Water SCHEMBL9810829 0.86 HRH3 (0.67) HRH3PYCR1HDAC8HDAC6CNR2
SCHEMBL12680476 0.86 HRH3 (1.00) HRH3TAAR1PYCR1HDAC8HDAC6
SCHEMBL14174788 0.85 CNR2 (0.58) HRH3KDM4ECNR2TSHRMAPK1
SCHEMBL24061143 0.83 HRH3 (0.84) HRH3PYCR1KCNH2
SCHEMBL12763732 0.83 HRH3 (0.75) HRH3TAAR1KDM4ECNR2TSHR
SCHEMBL12763738 0.82 CYP2C19 (0.63) HRH3CNR2TSHR
SCHEMBL12763746 0.82 BCHE (0.53) HRH3KDM4ECNR2TSHRMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140234763-A1 IMAGE FORMING APPARATUS AND PROCESS CARTRIDGE RICOH COMPANY, LTD. (JP) 2014-08-21 — — US disclosed
US-8486595-B2 Image bearing member, image forming apparatus, and process cartridge RICOH COMPANY, LTD. (JP) 2013-07-16 — — US disclosed
US-8273513-B2 Image forming apparatus, process cartridge, and image bearing member RICOH COMPANY, LIMITED (JP) 2012-09-25 — — US disclosed
US-20110059393-A1 IMAGE BEARING MEMBER, IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE RICOH COMPANY, LTD. (JP) 2011-03-10 — — US disclosed
US-20100330475-A1 IMAGE FORMING APPARATUS, PROCESS CARTRIDGE, AND IMAGE BEARING MEMBER RICOH COMPANY LIMITED (JP) 2010-12-30 — — US disclosed
US-20090180788-A1 Image forming apparatus, and image forming method RICOH COMPANY, LTD. (JP) 2009-07-16 — — US disclosed
US-20090180788-A1 Image forming apparatus, and image forming method RICOH COMPANY, LTD. (JP) 2009-07-16 — — US disclosed
US-20080227007-A1 Image forming apparatus and process cartridge RICOH COMPANY, LTD. 2008-09-18 — — US disclosed
US-20080227007-A1 Image forming apparatus and process cartridge RICOH COMPANY, LTD. 2008-09-18 — — US disclosed
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