Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 17/20 | 1.00 |
| ▸ | GAA | P10253 | 17/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 1.00 |
| ▸ | POLB | P06746 | 4/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 1.00 |
| ▸ | GFER | P55789 | 3/20 | 1.00 |
| ▸ | HPGD | P15428 | 2/20 | 1.00 |
| ▸ | HTT | P42858 | 3/20 | 0.80 |
| ▸ | LMNA | P02545 | 1/20 | 0.80 |
| ▸ | TP53 | P04637 | 1/20 | 0.80 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.74 |
| ▸ | MEN1 | O00255 | 7/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.74 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.74 |
| ▸ | RAB9A | P51151 | 9/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10280285 | 0.81 | MAPT (0.73) | MAPTGAAKDM4EPOLBTDP1 | |
| SCHEMBL880212 | 0.81 | PLA2G10 (0.72) | MAPTGAAKDM4EPOLBTDP1 | |
| SCHEMBL15359675 | 0.78 | MAPT (0.76) | MAPTGAAKDM4EPOLBTDP1 | |
| SCHEMBL10280287 | 0.78 | MAPT (0.76) | MAPTGAAKDM4EPOLBTDP1 | |
| SCHEMBL12162618 | 0.77 | GAA (0.69) | MAPTGAAKDM4EPOLBTDP1 | |
| SCHEMBL10280286 | 0.76 | MAPT (1.00) | MAPTGAAKDM4EPOLBTDP1 | |
| SCHEMBL13427293 | 0.76 | POLB (0.73) | MAPTGAAKDM4EPOLBTDP1 | |
| SCHEMBL880213 | 0.76 | MAPT (0.61) | MAPTGAAKDM4EPOLBTDP1 | |
| SCHEMBL880415 | 0.75 | MAPT (0.69) | MAPTGAAKDM4EPOLBTDP1 | |
| SCHEMBL880349 | 0.75 | GAA (1.00) | MAPTGAAKDM4EPOLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9643977-B2 | Necroptosis inhibitors and methods of use therefor | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-05-09 | — | — | US | disclosed |
| US-9643977-B2 | Necroptosis inhibitors and methods of use therefor | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-05-09 | — | — | US | disclosed |
| US-20140066466-A1 | Necroptosis Inhibitors and Methods of Use Therefor | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-03-06 | — | — | US | disclosed |
| US-20140066466-A1 | Necroptosis Inhibitors and Methods of Use Therefor | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-03-06 | — | — | US | disclosed |
| WO-2012125544-A2 | NECROPTOSIS INHIBITORS AND METHODS OF USE THEREFOR | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-09-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140066466-A1 | Necroptosis Inhibitors and Methods of Use Therefor | CD40, CD40LG, TNF | MAPT 3289/4885GAA 1797/4885KDM4E 2829/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.