Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMI1 | P35226 | 3/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.42 |
| ▸ | PDE2A | O00408 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12682814 | 0.85 | PIK3CD (0.43) | BMI1PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL8417967 | 0.83 | GRM2 (0.50) | BMI1RAB9APDE10AGRM2MEN1 | |
| SCHEMBL10816256 | 0.81 | PDE10A (0.54) | BMI1PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL12472856 | 0.79 | PIK3CD (0.54) | BMI1PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL11901798 | 0.79 | PIK3CD (0.54) | BMI1PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL11900852 | 0.77 | PIK3CD (0.59) | PIK3CDPIK3R1PIK3CAPIK3CBPIK3CG | |
| SCHEMBL2506882 | 0.77 | PIK3CD (0.59) | PIK3CDPIK3R1PIK3CAPIK3CBPIK3CG | |
| SCHEMBL12473083 | 0.76 | BMI1 (0.47) | BMI1PIK3CDPIK3R1PIK3CBPIK3CG | |
| Hydrochloric Acid SCHEMBL12473211 | 0.76 | PIK3CD (0.58) | PIK3CDPIK3R1PIK3CAPIK3CBPIK3CG | |
| SCHEMBL17938212 | 0.74 | MAP3K14 (0.41) | BMI1RAB9ACYP11B2CYP11B1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012107465-A1 | HETEROCYCLIC COMPOUNDS AS PI3 KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-08-16 | — | — | WO | disclosed |