SCHEMBL12683151

CC(C)(C)OC(=O)N1CCC[C@H]1c1ncc(-c2cc3oc4ccc(-c5ncc([C@@H]6CCCN6C(=O)OCc6ccccc6)[nH]5)cc4c(=O)c3cc2F)[nH]1

nearest known ligand 0.43

Predicted protein targets (top 11)

	gene	UniProt	supporting neighbours	confidence
▸	PRCP	P42785	11/20	0.42

▸	HPGDS	O60760	2/20	0.36

▸	PRMT5	O14744	1/20	0.36

▸	GPR119	Q8TDV5	1/20	0.36

▸	NR1I2	O75469	1/20	0.35

▸	MEN1	O00255	1/20	0.35

▸	ALDH1A1	P00352	1/20	0.35

▸	LMNA	P02545	1/20	0.35

▸	TSHR	P16473	1/20	0.35

▸	KMT2A	Q03164	1/20	0.35

▸	L3MBTL1	Q9Y468	1/20	0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL12682919	0.88	NR1I2 (0.52)	NR1I2
SCHEMBL15372091	0.88	PRCP (0.39)	PRCPHPGDSNR1I2
SCHEMBL10170973	0.87	PRCP (0.48)	PRCPHPGDSGPR119NR1I2
SCHEMBL10170989	0.86	PRCP (0.45)	PRCPHPGDSGPR119NR1I2
SCHEMBL12682947	0.85	PRCP (0.42)	PRCPHPGDSPRMT5
SCHEMBL12682910	0.85	PREP (0.38)	—
SCHEMBL12683231	0.84	PRMT5 (0.38)	PRCPPRMT5GPR119MEN1ALDH1A1
SCHEMBL12174997	0.82	PRCP (0.53)	PRCPHPGDS
SCHEMBL12682914	0.82	NR1H2 (0.37)	PRCP
SCHEMBL15372098	0.81	HCRTR1 (0.40)	—

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2012050918-A2	TRICYCLIC FUSED RING INHIBITORS OF HEPATITIS C	PRESIDIO PHARMACEUTICAL, INC. (US)	2012-04-19	—	—	WO	disclosed