Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 18/20 | 0.55 |
| ▸ | EED | O75530 | 2/20 | 0.47 |
| ▸ | RBBP4 | Q09028 | 2/20 | 0.47 |
| ▸ | SUZ12 | Q15022 | 2/20 | 0.47 |
| ▸ | RBBP7 | Q16576 | 2/20 | 0.47 |
| ▸ | EZH1 | Q92800 | 2/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12498358 | 0.85 | EZH2 (0.57) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL12180676 | 0.79 | EZH2 (0.71) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL15490805 | 0.78 | EZH2 (0.65) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL12180805 | 0.78 | EZH2 (0.67) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL12499156 | 0.78 | EZH2 (0.72) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL30387736 | 0.78 | EZH2 (0.72) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL12499957 | 0.78 | EZH2 (0.62) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL2591592 | 0.78 | EZH2 (0.70) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL12499131 | 0.77 | EZH2 (0.65) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL2592259 | 0.77 | EZH2 (0.67) | EZH2EEDRBBP4SUZ12RBBP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012118812-A2 | SUBSTITUTED 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS | Epizyme, Inc. (US) | 2012-09-07 | — | — | WO | disclosed |