Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 19/20 | 0.57 |
| ▸ | PIM3 | Q86V86 | 19/20 | 0.57 |
| ▸ | PIM2 | Q9P1W9 | 19/20 | 0.57 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12687550 | 0.87 | PIM1 (0.59) | PIM1PIM3PIM2GSK3B | |
| SCHEMBL12080337 | 0.87 | PIM2 (0.68) | PIM1PIM3PIM2GSK3BCYP3A4 | |
| SCHEMBL12687854 | 0.78 | PIM1 (0.62) | PIM1PIM3PIM2GSK3B | |
| SCHEMBL12079805 | 0.78 | PIM2 (0.69) | PIM1PIM3PIM2GSK3BCYP3A4 | |
| SCHEMBL12687470 | 0.78 | PIM3 (0.59) | PIM1PIM3PIM2GSK3BCYP3A4 | |
| SCHEMBL12687646 | 0.75 | PIM1 (0.56) | PIM1PIM3PIM2GSK3B | |
| SCHEMBL17115578 | 0.75 | PIM1 (0.90) | PIM1PIM3PIM2GSK3B | |
| SCHEMBL15613762 | 0.75 | PIM1 (0.90) | PIM1PIM3PIM2GSK3B | |
| SCHEMBL12079416 | 0.74 | PIM2 (0.68) | PIM1PIM3PIM2GSK3BCYP3A4 | |
| SCHEMBL9608899 | 0.72 | PIM1 (1.00) | PIM1PIM3PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012120415-A1 | TETRASUBSTITUTED CYCLOHEXYL COMPOUNDS AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-09-13 | — | — | WO | disclosed |