Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.71 |
| ▸ | BACE2 | Q9Y5Z0 | 6/20 | 0.61 |
| ▸ | CTSD | P07339 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL932018 | 0.88 | BACE1 (0.68) | BACE1BACE2 | |
| SCHEMBL6878085 | 0.88 | BACE1 (0.68) | BACE1BACE2 | |
| SCHEMBL18195492 | 0.88 | BACE1 (0.68) | BACE1BACE2 | |
| SCHEMBL2931081 | 0.85 | BACE1 (0.78) | BACE1BACE2 | |
| SCHEMBL2619828 | 0.85 | BACE1 (0.78) | BACE1BACE2 | |
| SCHEMBL967098 | 0.83 | BACE1 (0.62) | BACE1BACE2CTSDKCNH2 | |
| SCHEMBL934064 | 0.83 | BACE1 (0.62) | BACE1BACE2CTSDKCNH2 | |
| SCHEMBL6877100 | 0.83 | BACE1 (0.62) | BACE1BACE2CTSDKCNH2 | |
| Hydrochloric Acid SCHEMBL970513 | 0.82 | BACE1 (0.61) | BACE1BACE2CTSDKCNH2 | |
| SCHEMBL2926723 | 0.82 | BACE1 (0.55) | BACE1BACE2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2511269-A1 | FUSED HETEROCYCLIC COMPOUND HAVING AMINO GROUP | Shionogi & Co., Ltd. (JP) | 2012-10-17 | — | — | EP | disclosed |
| US-20120245155-A1 | FUSED HETEROCYCLIC COMPOUND HAVING AMINO GROUP | SHIONOGI & CO., LTD. (JP) | 2012-09-27 | — | — | US | disclosed |
| US-20120245155-A1 | FUSED HETEROCYCLIC COMPOUND HAVING AMINO GROUP | SHIONOGI & CO., LTD. (JP) | 2012-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120245155-A1 | FUSED HETEROCYCLIC COMPOUND HAVING AMINO GROUP | APP, IAPP, BACE1 | BACE1 3/4885BACE2 14/4885CTSD 2328/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.