Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.40 |
| ▸ | NUDT1 | P36639 | 3/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | PRKDC | P78527 | 2/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.34 |
| ▸ | PLK1 | P53350 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL179452 | 0.87 | PLK1 (0.42) | PIK3CDPIK3R1NUDT1ADORA2AADORA1 | |
| SCHEMBL179462 | 0.87 | PLK1 (0.42) | PIK3CDPIK3R1NUDT1ADORA2AADORA1 | |
| SCHEMBL179509 | 0.87 | PLK1 (0.42) | PIK3CDPIK3R1NUDT1ADORA2AADORA1 | |
| SCHEMBL12692515 | 0.85 | PIK3CD (0.37) | PIK3CDPIK3R1NUDT1ADORA2AADORA1 | |
| SCHEMBL12692538 | 0.85 | PIK3CD (0.37) | PIK3CDPIK3R1NUDT1ADORA2AADORA1 | |
| SCHEMBL251804 | 0.82 | PIK3CD (0.41) | PIK3CDPIK3R1NUDT1ADORA2AADORA1 | |
| SCHEMBL217591 | 0.82 | PIK3CD (0.41) | PIK3CDPIK3R1NUDT1ADORA2AADORA1 | |
| SCHEMBL250961 | 0.82 | PIK3CD (0.41) | PIK3CDPIK3R1NUDT1ADORA2AADORA1 | |
| SCHEMBL179430 | 0.81 | PIK3CD (0.38) | PIK3CDPIK3R1NUDT1ADORA2AADORA1 | |
| SCHEMBL179466 | 0.81 | PIK3CD (0.38) | PIK3CDPIK3R1NUDT1ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120245169-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | INTELLIKINE LLC | 2012-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120245169-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | PIK3CA, PIK3CG, PIK3CB | PIK3CD 4/4885PIK3R1 11/4885NUDT1 791/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.