Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 7/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.56 |
| ▸ | PLK4 | O00444 | 2/20 | 0.56 |
| ▸ | AURKC | Q9UQB9 | 2/20 | 0.56 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.56 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.56 |
| ▸ | STK25 | O00506 | 1/20 | 0.56 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.56 |
| ▸ | GAK | O14976 | 1/20 | 0.56 |
| ▸ | MUSK | O15146 | 1/20 | 0.56 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.56 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.56 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.56 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.56 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.56 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | ERN1 | O75460 | 1/20 | 0.56 |
| ▸ | STK16 | O75716 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12694156 | 0.91 | AURKB (0.56) | AURKAAURKBPLK4AURKCRIPK1 | |
| SCHEMBL12694113 | 0.91 | AURKA (0.56) | AURKAAURKBPLK4AURKCRIPK1 | |
| SCHEMBL12694122 | 0.91 | AURKB (0.66) | AURKAAURKBPLK4AURKCRIPK1 | |
| SCHEMBL12694155 | 0.88 | AURKA (0.54) | AURKAAURKBPLK4AURKCRIPK1 | |
| SCHEMBL12694112 | 0.88 | AURKB (0.54) | AURKAAURKBPLK4AURKCRIPK1 | |
| SCHEMBL12694185 | 0.88 | AURKA (0.54) | AURKAAURKBPLK4AURKCRIPK1 | |
| SCHEMBL12694138 | 0.86 | AURKA (0.45) | AURKAAURKBPLK4AURKCRIPK1 | |
| SCHEMBL12694118 | 0.85 | AURKB (0.54) | AURKAAURKBPLK4AURKCRIPK1 | |
| SCHEMBL13785836 | 0.85 | AURKB (0.52) | AURKAAURKBPLK4AURKCRIPK1 | |
| SCHEMBL12694116 | 0.83 | AURKA (0.51) | AURKAAURKBPLK4AURKCRIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012112674-A2 | COMPOUNDS AND METHODS OF USE THEREOF FOR TREATING NEURODEGENERATIVE DISORDERS | THE JOHNS HOPKINS UNIVERSITY (US) | 2012-08-23 | — | — | WO | disclosed |