Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 19/20 | 0.41 |
| ▸ | BACE2 | Q9Y5Z0 | 11/20 | 0.41 |
| ▸ | CTSD | P07339 | 5/20 | 0.33 |
| ▸ | REN | P00797 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL970149 | 0.88 | BACE1 (0.38) | BACE1BACE2CTSDRENABL1 | |
| SCHEMBL12694666 | 0.85 | BACE1 (0.49) | BACE1BACE2KCNH2CYP2D6 | |
| SCHEMBL14299103 | 0.84 | BACE1 (0.41) | BACE1BACE2CTSDREN | |
| SCHEMBL12851708 | 0.84 | BACE1 (0.41) | BACE1BACE2CTSDREN | |
| SCHEMBL932785 | 0.82 | BACE1 (0.55) | BACE1BACE2 | |
| SCHEMBL6877960 | 0.82 | BACE1 (0.55) | BACE1BACE2 | |
| SCHEMBL967378 | 0.82 | BACE1 (0.55) | BACE1BACE2 | |
| Hydrochloric Acid SCHEMBL969763 | 0.81 | BACE1 (0.54) | BACE1BACE2 | |
| SCHEMBL970151 | 0.80 | BACE1 (0.36) | BACE1BACE2CTSDREN | |
| SCHEMBL968862 | 0.80 | BACE1 (0.39) | BACE1BACE2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451793-B1 | BACE INHIBITORS | LILLY CO ELI (US) | 2016-11-02 | — | — | EP | disclosed |
| US-8278441-B2 | BACE inhibitors | ELI LILLY AND COMPANY (US) | 2012-10-02 | — | — | US | disclosed |