Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 12/20 | 0.53 |
| ▸ | EGFR | P00533 | 2/20 | 0.51 |
| ▸ | CDK9 | P50750 | 4/20 | 0.49 |
| ▸ | CCNK | O75909 | 3/20 | 0.49 |
| ▸ | CCND3 | P30281 | 3/20 | 0.49 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.49 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | PAK4 | O96013 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12694656 | 0.88 | CTSC (0.61) | BRD4EGFRCDK9ALKTNK2 | |
| SCHEMBL12854655 | 0.87 | EGFR (0.52) | BRD4EGFRCDK9CCNKCCND3 | |
| SCHEMBL13268187 | 0.82 | BRD4 (0.53) | BRD4EGFRCDK9CCNKCCND3 | |
| SCHEMBL12694807 | 0.80 | BRD4 (0.63) | BRD4EGFRCDK9CCNKCCND3 | |
| SCHEMBL3112959 | 0.79 | BRD4 (0.51) | BRD4EGFRALKJAK2RET | |
| SCHEMBL3115062 | 0.77 | TNK2 (0.55) | BRD4EGFRCDK9CCNKCCND3 | |
| SCHEMBL14481942 | 0.75 | BRD4 (0.50) | BRD4EGFRCDK2ALKTNK2 | |
| SCHEMBL3107379 | 0.74 | BRD4 (0.65) | BRD4EGFRCDK9CCNKCCND3 | |
| SCHEMBL3102212 | 0.74 | JAK1 (0.60) | BRD4EGFRJAK2JAK3 | |
| SCHEMBL12854649 | 0.74 | CTSC (0.58) | BRD4EGFRCDK9ALKTNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8278299-B2 | Pyrimidinediamine kinase inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2012-10-02 | — | — | US | disclosed |