Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 16/20 | 0.72 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.58 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.58 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.58 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.58 |
| ▸ | MTOR | P42345 | 1/20 | 0.58 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.58 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12693556 | 0.97 | PIK3CD (0.76) | PIK3CDPIK3CAPIK3R2PIK3C2BPIK3CB | |
| SCHEMBL12693555 | 0.89 | PIK3CD (0.57) | PIK3CDPIK3CAPIK3R2PIK3C2BPIK3CB | |
| SCHEMBL12539691 | 0.88 | PIK3CD (0.73) | PIK3CDPIK3CAPIK3R2PIK3C2BPIK3CB | |
| SCHEMBL12539274 | 0.86 | PIK3CD (0.82) | PIK3CDPIK3CAPIK3R2PIK3C2BPIK3CB | |
| SCHEMBL12539273 | 0.86 | PIK3CD (0.82) | PIK3CDPIK3CA | |
| SCHEMBL16937472 | 0.85 | PIK3CD (0.85) | PIK3CDPIK3CA | |
| SCHEMBL12539276 | 0.85 | PIK3CD (0.80) | PIK3CDPIK3CAPIK3R2PIK3C2BPIK3CB | |
| SCHEMBL12539726 | 0.85 | PIK3CD (0.93) | PIK3CDPIK3CAPIK3R2PIK3C2BPIK3CB | |
| SCHEMBL12690324 | 0.84 | PIK3CD (0.84) | PIK3CDPIK3CA | |
| SCHEMBL12540139 | 0.84 | PIK3CD (0.79) | PIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2688891-B1 | BENZOXAZEPIN COMPOUNDS SELECTIVE FOR PI3K P110 DELTA AND METHODS OF USE | HOFFMANN LA ROCHE (CH) | 2017-11-15 | — | — | EP | disclosed |
| US-9090628-B2 | Benzoxazepin compounds selective for PI3K P110 delta and methods of use | GENENTECH, INC. (US) | 2015-07-28 | — | — | US | disclosed |
| WO-2012126901-A1 | BENZOXAZEPIN COMPOUNDS SELECTIVE FOR PI3K P110 DELTA AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2012-09-27 | — | — | WO | disclosed |