Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 20/20 | 0.73 |
| ▸ | PIM3 | Q86V86 | 20/20 | 0.73 |
| ▸ | PIM2 | Q9P1W9 | 20/20 | 0.73 |
| ▸ | GSK3B | P49841 | 1/20 | 0.68 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.68 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12077606 | 0.96 | PIM1 (0.78) | PIM1PIM3PIM2GSK3BPRKCQ | |
| SCHEMBL12077609 | 0.90 | PIM1 (0.78) | PIM1PIM3PIM2GSK3BPRKCQ | |
| SCHEMBL15588858 | 0.87 | PIM2 (0.74) | PIM1PIM3PIM2 | |
| SCHEMBL12077755 | 0.87 | PIM2 (0.80) | PIM1PIM3PIM2GSK3BPRKCQ | |
| SCHEMBL12077751 | 0.87 | PIM2 (0.80) | PIM1PIM3PIM2GSK3BPRKCQ | |
| SCHEMBL3203765 | 0.85 | PIM1 (1.00) | PIM1PIM3PIM2GSK3BPRKCQ | |
| SCHEMBL3203752 | 0.85 | PIM1 (1.00) | PIM1PIM3PIM2GSK3BPRKCQ | |
| SCHEMBL12077297 | 0.85 | PIM2 (0.90) | PIM1PIM3PIM2GSK3BPRKCQ | |
| SCHEMBL12077299 | 0.85 | PIM2 (0.90) | PIM1PIM3PIM2GSK3BPRKCQ | |
| SCHEMBL12077947 | 0.85 | PIM2 (0.81) | PIM1PIM3PIM2GSK3BPRKCQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012120428-A1 | NOVEL KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-09-13 | — | — | WO | disclosed |