Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 12/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.38 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.38 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1660065 | 1.00 | SCN9A (0.40) | SCN9APDE2ATRPV1KCNQ3KCNQ2 | |
| SCHEMBL12604721 | 0.91 | PDE2A (0.39) | PDE2ATRPV1KCNQ3KCNQ2 | |
| SCHEMBL12563383 | 0.88 | PDE2A (0.44) | SCN9APDE2A | |
| SCHEMBL12604750 | 0.88 | TRPV1 (0.42) | PDE2ATRPV1KCNQ3KCNQ2 | |
| SCHEMBL1659587 | 0.88 | TRPV1 (0.42) | PDE2ATRPV1KCNQ3KCNQ2 | |
| SCHEMBL1987976 | 0.88 | PDE2A (0.41) | PDE2ATRPV1KCNQ3KCNQ2 | |
| SCHEMBL12603600 | 0.88 | PDE2A (0.41) | PDE2ATRPV1KCNQ3KCNQ2 | |
| SCHEMBL12604677 | 0.88 | PDE2A (0.44) | PDE2AKCNQ3KCNQ2 | |
| SCHEMBL1988302 | 0.88 | PDE2A (0.44) | PDE2AKCNQ3KCNQ2 | |
| SCHEMBL13513811 | 0.86 | KCNQ3 (0.40) | PDE2ATRPV1KCNQ3KCNQ2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307394-B1 | SULPHONAMIDES AS VANILLOID RECEPTOR ANTAGONIST | AMOREPACIFIC CORP (KR) | 2012-09-26 | — | — | EP | disclosed |
| WO-2010002209-A2 | NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | AMOREPACIFIC CORPORATION (KR) | 2010-01-07 | — | — | WO | disclosed |