Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 5/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.40 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.39 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.39 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | MME | P08473 | 2/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.35 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.35 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1987453 | 1.00 | PTGER4 (0.40) | PTGER4TRPV1KCNQ3KCNQ2KCNQ4 | |
| SCHEMBL1986290 | 0.91 | KCNQ3 (0.41) | KCNQ3KCNQ2KCNQ4KCNQ5KLKB1 | |
| SCHEMBL1985908 | 0.91 | KCNQ3 (0.39) | KCNQ3KCNQ2KCNQ4KCNQ5KLKB1 | |
| SCHEMBL12603598 | 0.91 | KCNQ3 (0.39) | KCNQ3KCNQ2KCNQ4KCNQ5KLKB1 | |
| SCHEMBL12603590 | 0.91 | KCNQ3 (0.41) | KCNQ3KCNQ2KCNQ4KCNQ5KLKB1 | |
| SCHEMBL12603906 | 0.90 | KCNQ3 (0.39) | KCNQ3KCNQ2KCNQ4KCNQ5KLKB1 | |
| SCHEMBL1990614 | 0.90 | KCNQ3 (0.39) | KCNQ3KCNQ2KCNQ4KCNQ5SCN9A | |
| SCHEMBL12697355 | 0.90 | KCNQ3 (0.39) | KCNQ3KCNQ2KCNQ4KCNQ5SCN9A | |
| SCHEMBL1660613 | 0.90 | KCNQ3 (0.39) | KCNQ3KCNQ2KCNQ4KCNQ5KLKB1 | |
| SCHEMBL12605014 | 0.88 | KCNQ3 (0.38) | KCNQ3KCNQ2KCNQ4KCNQ5KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307394-B1 | SULPHONAMIDES AS VANILLOID RECEPTOR ANTAGONIST | AMOREPACIFIC CORP (KR) | 2012-09-26 | — | — | EP | disclosed |
| WO-2010002209-A2 | NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | AMOREPACIFIC CORPORATION (KR) | 2010-01-07 | — | — | WO | disclosed |