Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 12/20 | 0.61 |
| ▸ | HCRTR2 | O43614 | 12/20 | 0.61 |
| ▸ | CDK8 | P49336 | 3/20 | 0.32 |
| ▸ | CDK19 | Q9BWU1 | 3/20 | 0.32 |
| ▸ | CCNC | P24863 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.30 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9948786 | 0.91 | HCRTR1 (0.72) | HCRTR1HCRTR2KDM4EALDH1A1HPGD | |
| SCHEMBL9949217 | 0.90 | HCRTR1 (0.59) | HCRTR1HCRTR2HPGDHSD17B10 | |
| SCHEMBL9949033 | 0.90 | HCRTR1 (0.59) | HCRTR1HCRTR2 | |
| SCHEMBL9948904 | 0.89 | HCRTR1 (0.57) | HCRTR1HCRTR2CDK8CDK19CCNC | |
| SCHEMBL9949343 | 0.87 | HCRTR1 (0.62) | HCRTR1HCRTR2KDM4E | |
| SCHEMBL9948825 | 0.87 | HCRTR1 (0.55) | HCRTR1HCRTR2KDM4EALDH1A1HPGD | |
| SCHEMBL9949052 | 0.86 | HCRTR1 (0.55) | HCRTR1HCRTR2KDM4E | |
| SCHEMBL9948796 | 0.86 | HCRTR1 (0.59) | HCRTR1HCRTR2KDM4EALDH1A1HPGD | |
| SCHEMBL9948746 | 0.86 | HCRTR2 (0.60) | HCRTR1HCRTR2KDM4EALDH1A1 | |
| SCHEMBL9948768 | 0.86 | HCRTR2 (0.60) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012101487-A1 | DI/TRI-AZA-SPIRO-C9-C11ALKANES | NOVARTIS AG (CH) | 2012-08-02 | — | — | WO | disclosed |