⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12701426 | 1.00 | — | — | |
| SCHEMBL12701101 | 0.78 | — | — | |
| SCHEMBL17414068 | 0.74 | — | — | |
| SCHEMBL17414071 | 0.74 | — | — | |
| SCHEMBL12701422 | 0.74 | — | — | |
| SCHEMBL17414095 | 0.72 | — | — | |
| SCHEMBL16070113 | 0.72 | — | — | |
| SCHEMBL16070118 | 0.71 | — | — | |
| SCHEMBL16070441 | 0.70 | — | — | |
| SCHEMBL17414093 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9428750-B2 | Oligomeric compounds comprising tricyclic nucleosides and methods for their use | IONIS PHARMACEUTICALS, INC. (US) | 2016-08-30 | — | — | US | disclosed |
| US-20150259681-A1 | OLIGOMERIC COMPOUNDS COMPRISING TRICYCLIC NUCELOSIDES AND METHODS FOR THEIR USE | ISIS PHARMACEUTICALS, INC. (US) | 2015-09-17 | — | — | US | disclosed |
| US-8993528-B2 | Oligomeric compounds comprising tricyclic nucelosides and methods for their use | ISIS PHARMACEUTICALS, INC. (US) | 2015-03-31 | — | — | US | disclosed |
| US-20130197062-A1 | OLIGOMERIC COMPOUNDS COMPRISING TRICYCLIC NUCELOSIDES AND METHODS FOR THEIR USE | ISIS PHARMACEUTICALS, INC. (US) | 2013-08-01 | — | — | US | disclosed |
| US-8426378-B2 | Oligomeric compounds comprising tricyclic nucelosides and methods for their use | ISIS PHARMACEUTICALS, INC. (US) | 2013-04-23 | — | — | US | disclosed |
| US-20110092570-A1 | OLIGOMERIC COMPOUNDS COMPRISING TRICYCLIC NUCELOSIDES AND METHODS FOR THEIR USE | IONIS PHARMACEUTICALS, INC. | 2011-04-21 | — | — | US | disclosed |