Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 11/20 | 0.61 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.54 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1195819 | 0.85 | NR1H3 (0.76) | PTGS1NR1H3PTPN1NR1H2 | |
| SCHEMBL12450164 | 0.85 | NR1H3 (0.76) | PTGS1NR1H3PTPN1NR1H2 | |
| SCHEMBL267301 | 0.85 | NR1H3 (0.76) | PTGS1NR1H3PTPN1NR1H2 | |
| SCHEMBL280037 | 0.84 | NR1H3 (0.54) | PTGS1NR1H3PTPN1NR1H2 | |
| SCHEMBL280219 | 0.84 | PTGS1 (0.59) | PTGS1NR1H3PTPN1NR1H2 | |
| SCHEMBL12704693 | 0.83 | PTGS1 (0.60) | PTGS1NR1H3PTPN1NR1H2 | |
| SCHEMBL280222 | 0.83 | PTGS1 (0.64) | PTGS1NR1H3PTPN1NR1H2 | |
| SCHEMBL6009584 | 0.82 | PTGS1 (0.61) | PTGS1NR1H3PTPN1NR1H2 | |
| SCHEMBL12704603 | 0.81 | PTGS1 (0.60) | PTGS1NR1H3PTPN1NR1H2 | |
| SCHEMBL280334 | 0.80 | PTGS1 (0.58) | PTGS1NR1H3PTPN1NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2311795-A2 | Interleukin-1 and tumor necrosis factor-alpha modulators; syntheses of such modulators and methods of using such modulators | Nereus Pharmaceuticals, Inc. (US) | 2011-04-20 | — | — | EP | disclosed |