Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 2/20 | 0.58 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.47 |
| ▸ | RXRA | P19793 | 2/20 | 0.46 |
| ▸ | RXRB | P28702 | 2/20 | 0.46 |
| ▸ | RXRG | P48443 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | POLA1 | P09884 | 4/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL267305 | 1.00 | NR1H3 (0.58) | NR1H3PTPN1PTGS1RXRARXRB | |
| SCHEMBL12704621 | 1.00 | NR1H3 (0.58) | NR1H3PTPN1PTGS1RXRARXRB | |
| SCHEMBL14610508 | 1.00 | NR1H3 (0.58) | NR1H3PTPN1PTGS1RXRARXRB | |
| SCHEMBL266932 | 1.00 | NR1H3 (0.58) | NR1H3PTPN1PTGS1RXRARXRB | |
| SCHEMBL6008298 | 1.00 | NR1H3 (0.58) | NR1H3PTPN1PTGS1RXRARXRB | |
| SCHEMBL12450204 | 0.89 | NR1H3 (0.47) | NR1H3PTPN1PTGS1RXRARXRB | |
| SCHEMBL267557 | 0.89 | NR1H3 (0.47) | NR1H3PTPN1PTGS1RXRARXRB | |
| SCHEMBL12887758 | 0.87 | PTGS1 (0.46) | NR1H3PTPN1PTGS1POLA1 | |
| SCHEMBL267488 | 0.87 | PTGS1 (0.46) | NR1H3PTPN1PTGS1POLA1 | |
| SCHEMBL6008134 | 0.87 | PTGS1 (0.46) | NR1H3PTPN1PTGS1POLA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2311795-A2 | Interleukin-1 and tumor necrosis factor-alpha modulators; syntheses of such modulators and methods of using such modulators | Nereus Pharmaceuticals, Inc. (US) | 2011-04-20 | — | — | EP | disclosed |