Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 16/20 | 0.65 |
| ▸ | EGFR | P00533 | 5/20 | 0.64 |
| ▸ | MET | P08581 | 5/20 | 0.64 |
| ▸ | SRC | P12931 | 3/20 | 0.64 |
| ▸ | KIT | P10721 | 2/20 | 0.52 |
| ▸ | TBKBP1 | A7MCY6 | 1/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | GAK | O14976 | 1/20 | 0.51 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.51 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.51 |
| ▸ | ERN1 | O75460 | 1/20 | 0.51 |
| ▸ | STK10 | O94804 | 1/20 | 0.51 |
| ▸ | FYN | P06241 | 1/20 | 0.51 |
| ▸ | YES1 | P07947 | 1/20 | 0.51 |
| ▸ | LYN | P07948 | 1/20 | 0.51 |
| ▸ | FER | P16591 | 1/20 | 0.51 |
| ▸ | MARK3 | P27448 | 1/20 | 0.51 |
| ▸ | ECHS1 | P30084 | 1/20 | 0.51 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13667291 | 0.95 | AXL (0.61) | AXLEGFRMETSRCTBKBP1 | |
| SCHEMBL13667270 | 0.92 | AXL (0.64) | AXLEGFRMETSRCKIT | |
| SCHEMBL13667534 | 0.90 | AXL (0.66) | AXLEGFRMETSRC | |
| SCHEMBL1546671 | 0.89 | AXL (0.81) | AXLEGFRMETSRCTBKBP1 | |
| SCHEMBL13667531 | 0.87 | AXL (0.60) | AXLEGFRMETSRCTBKBP1 | |
| SCHEMBL1591271 | 0.84 | AXL (0.76) | AXLEGFRMETSRCTBKBP1 | |
| SCHEMBL13667271 | 0.84 | AXL (0.66) | AXLEGFRMETSRCTBKBP1 | |
| SCHEMBL1546627 | 0.83 | AXL (0.75) | AXLEGFRMETSRCTBKBP1 | |
| SCHEMBL1547357 | 0.83 | AXL (0.82) | AXLEGFRMETSRCTBKBP1 | |
| SCHEMBL1546618 | 0.82 | AXL (0.77) | AXLEGFRMETSRCTBKBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011045084-A1 | QUINOLINYLOXYPHENYLSULFONAMIDES | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2011-04-21 | — | — | WO | disclosed |
| EP-2311809-A1 | Quinolinyloxyphenylsulfonamides | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2011-04-20 | — | — | EP | disclosed |