Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 16/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | CDK7 | P50613 | 2/20 | 0.39 |
| ▸ | CCNH | P51946 | 2/20 | 0.39 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | CCNK | O75909 | 1/20 | 0.38 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1634242 | 0.94 | HRH3 (0.44) | HRH3CDK4CCND1CDK6CCNA2 | |
| SCHEMBL12724903 | 0.90 | CDK4 (0.47) | CDK4CCND1CDK6CCNA2CDK2 | |
| SCHEMBL12724921 | 0.87 | SYK (0.44) | HRH3CDK4CCND1CDK6 | |
| SCHEMBL1632964 | 0.87 | USP2 (0.49) | CCNA2CDK2 | |
| SCHEMBL13498327 | 0.85 | IKBKB (0.43) | CHEK1 | |
| SCHEMBL1633930 | 0.84 | HRH3 (0.43) | HRH3CDK4CCND1CDK6 | |
| SCHEMBL1632568 | 0.84 | HRH3 (0.43) | HRH3CDK4CCND1CDK6 | |
| SCHEMBL1634267 | 0.83 | CDK4 (0.50) | CDK4CCND1CDK6CCNA2CDK2 | |
| SCHEMBL1633595 | 0.82 | HRH3 (0.43) | HRH3CDK4CCND1CDK6 | |
| SCHEMBL1634281 | 0.81 | HRH3 (0.48) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |