Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 2/20 | 0.57 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.57 |
| ▸ | ALK | Q9UM73 | 9/20 | 0.53 |
| ▸ | EGFR | P00533 | 4/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.49 |
| ▸ | PLK1 | P53350 | 4/20 | 0.49 |
| ▸ | IGF1R | P08069 | 4/20 | 0.48 |
| ▸ | INSR | P06213 | 3/20 | 0.48 |
| ▸ | PLK4 | O00444 | 3/20 | 0.48 |
| ▸ | DCLK1 | O15075 | 3/20 | 0.48 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.48 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | PI4KA | P42356 | 1/20 | 0.48 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.48 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12728756 | 0.92 | ZAP70 (0.66) | ZAP70ALKEGFRMAPK8MAPK9 | |
| SCHEMBL12781155 | 0.87 | ZAP70 (0.74) | ULK1ZAP70ALKEGFRMAPK8 | |
| SCHEMBL12728746 | 0.85 | ZAP70 (0.54) | ULK1ZAP70ALKEGFRPLK1 | |
| SCHEMBL12728755 | 0.84 | ZAP70 (0.64) | ZAP70ALKEGFRMAPK8MAPK9 | |
| SCHEMBL12728753 | 0.84 | ZAP70 (0.64) | ZAP70ALKEGFRMAPK8MAPK9 | |
| SCHEMBL12728752 | 0.84 | ZAP70 (0.63) | ZAP70ALKEGFRMAPK8MAPK9 | |
| SCHEMBL12728751 | 0.83 | ZAP70 (0.66) | ZAP70ALKEGFRMAPK8MAPK9 | |
| SCHEMBL12728760 | 0.83 | ZAP70 (0.66) | ZAP70ALKEGFRMAPK8MAPK9 | |
| SCHEMBL12728761 | 0.83 | ZAP70 (0.68) | ZAP70ALKEGFRMAPK8MAPK9 | |
| SCHEMBL12728533 | 0.81 | ZAP70 (0.59) | ULK1ZAP70ALKEGFRMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110098280-A1 | 2,4-PYRIMIDINEDIAMINES USEFUL IN THE TREATMENT OF NEOPLASTIC DISEASES, INFLAMMATORY AND IMMUNE SYSTEM DISORDERS | NOVARTIS AG (CH) | 2011-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110098280-A1 | 2,4-PYRIMIDINEDIAMINES USEFUL IN THE TREATMENT OF NEOPLASTIC DISEASES, INFLAMMATORY AND IMMUNE SYSTEM DISORDERS | TYMS, TYMP, DPYD | ULK1 2595/4885ZAP70 341/4885ALK 3384/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.