Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 10/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.49 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1426842 | 0.84 | PTGER4 (0.51) | HDAC1HDAC6MAPTPTGER4PTGER2 | |
| SCHEMBL12734992 | 0.83 | HDAC1 (0.51) | HDAC1HDAC6MAPTSMN1; SMN2PTGER4 | |
| SCHEMBL12735007 | 0.83 | PTGER4 (0.49) | HDAC1HDAC6MAPTPTGER4PTGER2 | |
| SCHEMBL4056244 | 0.80 | HDAC1 (0.75) | HDAC1HDAC6MAPTSMN1; SMN2TP53 | |
| SCHEMBL12735012 | 0.79 | PTGER4 (0.48) | HDAC1HDAC6PTGER4PTGER2 | |
| SCHEMBL12735000 | 0.79 | PTGER4 (0.50) | HDAC1HDAC6PTGER4PTGER2 | |
| SCHEMBL13249550 | 0.79 | PTGER4 (0.64) | HDAC1HDAC6PTGER4PTGER2HPGD | |
| SCHEMBL12734999 | 0.78 | PTGER4 (0.53) | HDAC1HDAC6PTGER4PTGER2 | |
| SCHEMBL12735042 | 0.78 | PTGER4 (0.50) | HDAC1HDAC6PTGER4PTGER2 | |
| SCHEMBL13249295 | 0.77 | PTGER4 (0.65) | HDAC1HDAC6PTGER4PTGER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110082133-A1 | PYRIDONE COMPOUNDS | ASTELLAS PHARMA INC. (JP) | 2011-04-07 | — | — | US | disclosed |
| US-20110082133-A1 | PYRIDONE COMPOUNDS | ASTELLAS PHARMA INC. (JP) | 2011-04-07 | — | — | US | disclosed |
| EP-2301922-A1 | PYRIDONE COMPOUND | Astellas Pharma Inc. (JP) | 2011-03-30 | — | — | EP | disclosed |
| WO-2009154190-A1 | PYRIDONE COMPOUND | アステラス製薬株式会社 (JP) | 2009-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110082133-A1 | PYRIDONE COMPOUNDS | PTGER4, P2RY4, PTGER1 | HDAC1 3199/4885HDAC6 4278/4885MAPT 4748/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.