Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 6/20 | 0.54 |
| ▸ | RET | P07949 | 1/20 | 0.52 |
| ▸ | AXL | P30530 | 3/20 | 0.52 |
| ▸ | KIT | P10721 | 1/20 | 0.52 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.52 |
| ▸ | AURKA | O14965 | 3/20 | 0.51 |
| ▸ | LCK | P06239 | 3/20 | 0.51 |
| ▸ | TEK | Q02763 | 3/20 | 0.51 |
| ▸ | MET | P08581 | 2/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | LYN | P07948 | 1/20 | 0.49 |
| ▸ | FLT1 | P17948 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1471959 | 0.90 | AXL (0.60) | KDRPDGFRARETAXLKIT | |
| SCHEMBL1471825 | 0.90 | RET (0.60) | KDRPDGFRARETAXLKIT | |
| SCHEMBL1472160 | 0.87 | RET (0.58) | KDRPDGFRARETAXLKIT | |
| SCHEMBL1471406 | 0.86 | MAPT (0.69) | KDRPDGFRARETAXLKIT | |
| SCHEMBL1472127 | 0.86 | RET (0.59) | KDRPDGFRARETAXLKIT | |
| SCHEMBL1471744 | 0.86 | PDGFRA (0.60) | KDRPDGFRARETAXLKIT | |
| SCHEMBL1472072 | 0.85 | RET (0.61) | KDRPDGFRARETAXLKIT | |
| SCHEMBL1471628 | 0.85 | RET (0.53) | KDRPDGFRARETAXLKIT | |
| SCHEMBL1472518 | 0.85 | AXL (0.55) | KDRPDGFRARETAXLKIT | |
| SCHEMBL1472517 | 0.85 | KDR (0.66) | KDRPDGFRAAXLKITFGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7915287-B2 | Use treating hepatocyte growth factor (HGF)-mediated diseases such as cancer; inhibitors of c-Met; e.g. 3-(3-fluoro-4-(7-methoxyquinolin-4-yloxy)phenylamino)-N-phenylpyrazine-2-carboxamide | AMGEN INC. (US) | 2011-03-29 | — | — | US | disclosed |