Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XIAP | P98170 | 5/20 | 0.61 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12757268 | 0.86 | XIAP (0.63) | XIAPMEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL12757264 | 0.83 | XIAP (0.82) | XIAPMEN1KMT2AALDH1A1HSD17B10 | |
| SCHEMBL12757271 | 0.79 | XIAP (0.59) | XIAPMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL12757265 | 0.77 | XIAP (1.00) | XIAPMEN1KMT2AALDH1A1HSD17B10 | |
| SCHEMBL12757272 | 0.74 | XIAP (0.55) | XIAPMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL12757286 | 0.71 | XIAP (0.80) | XIAPMEN1KMT2AALDH1A1HSD17B10 | |
| SCHEMBL12757266 | 0.71 | XIAP (0.74) | XIAPMEN1KMT2AALDH1A1HSD17B10 | |
| SCHEMBL29332849 | 0.70 | TSHR (0.58) | CA1CA2MEN1KMT2ATSHR | |
| SCHEMBL14302225 | 0.70 | SMN1; SMN2 (0.48) | XIAPMEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL29032728 | 0.69 | HPGD (0.64) | CA1CA2MEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7910621-B2 | Small molecule antagonists of XIAP family proteins | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-03-22 | — | — | US | disclosed |
| US-7910621-B2 | Small molecule antagonists of XIAP family proteins | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-03-22 | — | — | US | disclosed |
| US-20080021095-A1 | Small Molecule Antagonists of Xiap Family Proteins | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2008-01-24 | — | — | US | disclosed |
| US-20080021095-A1 | Small Molecule Antagonists of Xiap Family Proteins | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2008-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080021095-A1 | Small Molecule Antagonists of Xiap Family Proteins | XIAP, BIRC5, BIRC3 | XIAP 1/4885CA1 4694/4885CA2 4787/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.