Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 11/20 | 0.77 |
| ▸ | ITGA2 | P17301 | 7/20 | 0.77 |
| ▸ | ITGAV | P06756 | 2/20 | 0.49 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 5/20 | 0.39 |
| ▸ | MMP3 | P08254 | 5/20 | 0.39 |
| ▸ | MMP7 | P09237 | 5/20 | 0.39 |
| ▸ | MMP2 | P08253 | 4/20 | 0.39 |
| ▸ | MMP13 | P45452 | 4/20 | 0.39 |
| ▸ | ITGA5 | P08648 | 3/20 | 0.39 |
| ▸ | MMP9 | P14780 | 2/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1487439 | 1.00 | ITGB1 (0.77) | ITGB1ITGA2ITGAVITGA4ALDH1A1 | |
| SCHEMBL1487447 | 0.87 | ITGB1 (0.83) | ITGB1ITGA2ITGAVITGA4ALDH1A1 | |
| SCHEMBL21376388 | 0.87 | ITGB1 (1.00) | ITGB1ITGA2ITGAVITGA4ALDH1A1 | |
| SCHEMBL4253453 | 0.87 | ITGB1 (1.00) | ITGB1ITGA2ITGAVITGA4ALDH1A1 | |
| SCHEMBL31001648 | 0.87 | ITGB1 (1.00) | ITGB1ITGA2ITGAVITGA4ALDH1A1 | |
| SCHEMBL12084520 | 0.87 | ITGB1 (1.00) | ITGB1ITGA2ITGAVITGA4ALDH1A1 | |
| SCHEMBL1487361 | 0.85 | ITGB1 (0.81) | ITGB1ITGA2ITGAVITGA4ALDH1A1 | |
| SCHEMBL1487445 | 0.85 | ITGB1 (0.85) | ITGB1ITGA2ITGAVITGA4ALDH1A1 | |
| SCHEMBL1487436 | 0.84 | ITGB1 (0.81) | ITGB1ITGA2ITGAVITGA4MMP1 | |
| SCHEMBL1487440 | 0.84 | ITGB1 (0.90) | ITGB1ITGA2ITGAVITGA4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7910609-B2 | Inhibitors of integrin alpha2beta1 with modified urea moiety | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2011-03-22 | — | — | US | disclosed |
| US-7910609-B2 | Inhibitors of integrin alpha2beta1 with modified urea moiety | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2011-03-22 | — | — | US | disclosed |