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Sugi Predict / Compounds / SCHEMBL1276196

SCHEMBL1276196

SCHEMBL1276196

Cc1cccc(Nc2c(C(N)=O)cnc3c(Cl)cc(S(C)(=O)=O)cc23)c1.Cc1cncc(Nc2c(C(N)=O)cnc3c(C)cc(S(C)(=O)=O)cc23)c1

nearest known ligand 0.64

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ PDE4B Q07343 16/20 0.64
▸ CSF1R P07333 4/20 0.47
▸ LRRK2 Q5S007 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2475317 0.91 PDE4B (0.64) PDE4BCSF1RLRRK2
SCHEMBL1276147 0.89 PDE4B (0.65) PDE4BCSF1RLRRK2
SCHEMBL1276400 0.83 PDE4B (0.64) PDE4BCSF1RLRRK2
Hydrochloric Acid SCHEMBL2478762 0.82 PDE4B (0.63) PDE4BCSF1RLRRK2
SCHEMBL1275872 0.82 PDE4B (0.61) PDE4BCSF1RLRRK2
SCHEMBL2480839 0.81 PDE4B (0.72) PDE4BCSF1RLRRK2
SCHEMBL1276135 0.81 PDE4B (0.75) PDE4BCSF1RLRRK2
SCHEMBL2482135 0.80 PDE4B (0.67) PDE4BCSF1RLRRK2
SCHEMBL2481381 0.79 PDE4B (0.82) PDE4BCSF1RLRRK2
SCHEMBL1275345 0.78 PDE4B (1.00) PDE4BCSF1RLRRK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4625460-B2 — — 2011-02-02 — — JP claimed
JP-2007501264-A — — 2007-01-25 — — JP claimed
EP-1633748-A1 QUINOLINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS GLAXO GROUP LIMITED (GB) 2006-03-15 — — EP claimed
WO-2004103998-A1 QUINOLINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS GLAXO GROUP LIMITED (GB) 2004-12-02 — — WO claimed