Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Eritoran. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 known ✓ | O00206 | 19/20 | 1.00 |
| ▸ | LY96 known ✓ | Q9Y6Y9 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Eritoran SCHEMBL12836754 | 1.00 | TLR4 (1.00) | TLR4LY96 | |
| Eritoran SCHEMBL10071635 | 1.00 | TLR4 (1.00) | TLR4LY96 | |
| Eritoran SCHEMBL13302901 | 1.00 | TLR4 (1.00) | TLR4LY96 | |
| Eritoran SCHEMBL10042165 | 1.00 | TLR4 (1.00) | TLR4LY96 | |
| Eritoran SCHEMBL10042160 | 1.00 | TLR4 (1.00) | TLR4LY96 | |
| Eritoran SCHEMBL10071018 | 1.00 | TLR4 (1.00) | TLR4LY96 | |
| Eritoran SCHEMBL12371609 | 1.00 | TLR4 (1.00) | TLR4LY96 | |
| Eritoran SCHEMBL14081112 | 1.00 | TLR4 (1.00) | TLR4LY96 | |
| Eritoran SCHEMBL21378839 | 1.00 | TLR4 (1.00) | TLR4LY96 | |
| Eritoran SCHEMBL10042156 | 1.00 | TLR4 (1.00) | TLR4LY96 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7906633-B2 | Reagents and methods for preparing LPS antagonist B1287 and stereoisomers thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-03-15 | — | — | US | disclosed |